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This study manifested that phase II detoxification enzymes such as GST1, GSTK1, GST3 were up-regulated under chronic exposure to AFB1 (308), though previous studies found that these genes were down-regulated or not significantly influenced due to the difference between animal models selected for omics-based investigations (308, 309)

4.2 Antioxidant Considerations Exercise at moderate altitudes is associated with increased production of RONS with reduced antioxidant capacity, leading to oxidative stress [72, 73]

Consequently, the downregulation of genes essential for BTB integrity may adversely affect seminiferous tubule structure

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Better understandings of its interactions with pro-angiogenic and inflammatory mechanisms would be useful to refine its application, as well as comparisons with other classic inhibitors of angiogenesis, which would highlight the unique effects of SCPs